Viral Tropism
نویسندگان
چکیده
The authors in this Research Topic have highlighted the importance of viral tropism by presenting biological phenomena and their underpinning host cellular and molecular bases. The biologically unique phenomenon of viral tropism is not only of interest to virologists to bring progress to their basic science but also highly relevant to clinical studies with the goal to design new anti-viral strategies. Accordingly, “Viral Tropism” must be considered a sibling to another Research Topic in Frontiers in Virology entitled “Receptor usage and pathogenesis in acute and chronic viral infection.”
منابع مشابه
Evaluation of H9N2 avian influenza virus dissemination in various organs of experimentally infected broiler chickens using RT-PCR
Widespread occurrence of H9N2 low pathogenic avian influenza (LPAI) viruses in many Asian countriesduring the past decade has resulted in the need for evaluation of the pathogenesis of H9N2 virus infection. In this study, tissue tropism and dissemination of A/Chicken/Iran/772/1998(H9N2) virus throughout the body of broiler chickens were investigated. The clinical signs, gross lesions and antibo...
متن کاملHigh concordance of genotypic coreceptor prediction in plasma-viral RNA and proviral DNA of HIV-1 subtype C: implications for use of whole blood DNA in resource-limited settings.
OBJECTIVES Genotypic tropism testing (GTT) of HIV is increasingly used prior to the initiation of CCR5 antagonist therapy in HIV-infected individuals. Normally performed on plasma-derived virus, the test is challenging when performed in patients with suppressed viraemia. We aimed to evaluate the performance of cell-associated proviral DNA against plasma-derived viral RNA as the genetic material...
متن کاملPossible involvement of distinct phylogenetic clusters of HIV-1 variants in the discrepancies between coreceptor tropism predictions based on viral RNA and proviral DNA
BACKGROUND The coreceptor tropism testing should be conducted prior to commencing a regimen containing a CCR5 antagonist for treatment of HIV-1 infection. For aviremic patients on long antiretroviral therapy, proviral DNA is often used instead of viral RNA in genotypic tropism testing. However, the tropism predictions from RNA and DNA are sometimes different. We examined the cause of the discre...
متن کاملDetermination of HIV-1 coreceptor tropism using proviral DNA in women before and after viral suppression
BACKGROUND An HIV-1 tropism test is recommended prior to CCR5 antagonist administration to exclude patients harboring non-R5 virus from treatment with this class of antiretrovirals. HIV-1 tropism determination based on proviral DNA (pvDNA) may be useful in individuals with plasma viral RNA suppression. We developed a genotypic tropism assay for pvDNA and assessed its performance in a retrospect...
متن کاملHIV-1 tropism evolution after short-term maraviroc monotherapy in HIV-1-infected patients.
We analyzed the evolution of viral tropism after 8 days of maraviroc monotherapy, i.e., we used the maraviroc clinical test (MCT), in 21 patients with and 14 without virological response to the drug (MCT(+) and MCT(-) patients, respectively). No increases in CXCR4 inferred viral loads (X4IVLs) were observed in MCT(+) patients, while X4IVLs increased only in MCT(-) patients, with X4IVLs of >2 lo...
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